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Article

RNA dependent suppression of C9orf72 ALS/FTD associated neurodegeneration by Matrin-3

31 Oct 2020

Abstract excerpt

The most common genetic cause of amyotrophic lateral sclerosis (ALS) is a GGGGCC (G4C2) hexanucleotide repeat expansions in first intron of the C9orf72 gene. The accumulation of repetitive RNA sequences can mediate toxicity potentially through the formation of intranuclear RNA foci that sequester key RNA-binding proteins (RBPs), and non-ATG mediated translation into toxic dipeptide protein repeats. However, the...

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PMID: 33129345
DOI: 10.1186/s40478-020-01060-y

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