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Article

MATR3 P154S knock-in mice do not exhibit motor, muscle or neuropathologic features of ALS.

Biochemical and biophysical research communications - 19 Feb 2023

Dominick Marissa, Houchins Nicole, Venugopal Vinisha, Zuberi Aamir R, Lutz Cathleen M, Meechooveet Bessie, Van Keuren-Jensen Kendall, Bowser Robert, Medina David X

Abstract excerpt

Matrin 3 is a nuclear matrix protein that has many roles in RNA processing including splicing and transport of mRNA. Many missense mutations in the Matrin 3 gene (MATR3) have been linked to familial forms of amyotrophic lateral sclerosis (ALS) and distal myopathy. However, the exact role of MATR3 mutations in ALS and myopathy pathogenesis is not understood. To demonstrate a role of MATR3 mutations in vivo, we...

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Identifiers

PMID: 36689813
DOI: 10.1016/j.bbrc.2023.01.032
PMCID: PMC10046992

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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