Article
Novel metastatic models of esophageal adenocarcinoma derived from FLO-1 cells highlight the importance of E-cadherin in cancer metastasis.
Oncotarget - 13 Dec 2016
Liu David S, Hoefnagel Sanne J M, Fisher Oliver M, Krishnadath Kausilia K, Montgomery Karen G, Busuttil Rita A, Colebatch Andrew J, Read Matthew, Duong Cuong P, Phillips Wayne A, Clemons Nicholas J
Abstract excerpt
There is currently a paucity of preclinical models available to study the metastatic process in esophageal cancer. Here we report FLO-1, and its isogenic derivative FLO-1LM, as two spontaneously metastatic cell line models of human esophageal adenocarcinoma. We show that FLO-1 has undergone epithelial-mesenchymal transition and metastasizes following subcutaneous injection in mice. FLO-1LM, derived from a FLO-1...
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