Article
Understanding metastatic SCCHN cells from unique genotypes to phenotypes with the aid of an animal model and DNA microarray analysis.
Clinical & experimental metastasis - 1 Jan 2006
Zhang Xin, Su Ling, Pirani Ali A, Wu Haiyan, Zhang Hongzheng, Shin Dong M, Gernert Kim M, Chen Zhuo Georgia
Abstract excerpt
Metastasis of squamous cell carcinoma of the head and neck (SCCHN) is a significant health-care problem worldwide. The 5-year survival rate is less than 50% for patients with lymph node metastases. Understanding the molecular basis of SCCHN metastasis would facilitate the development of new therapeutic approaches to the disease. To identify proteins that mediate SCCHN metastasis, we established a SCCHN xenograft...
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