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Article

FAT1: a potential target for monoclonal antibody therapy in colon cancer.

British journal of cancer - 28 Jun 2016

Pileri Piero, Campagnoli Susanna, Grandi Alberto, Parri Matteo, De Camilli Elisa, Song Chaojun, Ganfini Luisa, Lacombe Aurelien, Naldi Ilaria, Sarmientos Paolo, Cinti Caterina, Jin Boquan, Grandi Guido, Viale Giuseppe, Terracciano Luigi, Grifantini Renata

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) is one of the major causes of cancer-associated mortality worldwide. The currently approved therapeutic agents have limited efficacy. METHODS: The atypical cadherin FAT1 was discovered as a novel CRC-associated protein by using a monoclonal antibody (mAb198.3). FAT1 expression was assessed in CRC cells by immunohistochemistry (IHC), immunoblots, flow cytometry and confocal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27328312
DOI: 10.1038/bjc.2016.145
PMCID: PMC4931367

Genes

FAT1
BRAF
EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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