Article
Phenotypically resembling myeloid derived suppressor cells are increased in children with HIV and exposed/infected with Mycobacterium tuberculosis.
European journal of immunology - 1 Jan 2017
Du Plessis Nelita, Jacobs Ruschca, Gutschmidt Andrea, Fang Zhuo, van Helden Paul D, Lutz Manfred B, Hesseling Anneke C, Walzl Gerhard
Abstract excerpt
Increased disease susceptibility during early life has been linked to immune immaturity, regulatory T-cell/TH2 immune biasing and hyporesponsiveness. The contribution of myeloid derived suppressor cells (MDSCs) remains uninvestigated. Here, we assessed peripheral MDSC in HIV-infected and -uninfected children with tuberculosis (TB) disease before, during and after TB treatment, along with matched household...
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