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Mechanisms of copy number variants in neuropsychiatric disorders: From genes to therapeutics.

Current opinion in neurobiology - 1 Oct 2023

Forrest Marc P, Penzes Peter

Abstract excerpt

Copy number variants (CNVs) are genomic imbalances strongly linked to the aetiology of neuropsychiatric disorders such as schizophrenia and autism. By virtue of their large size, CNVs often contain many genes, providing a multi-genic view of disease processes that can be dissected in model systems. Thus, CNV research provides an important stepping stone towards understanding polygenic disease mechanisms,...

Topics

Humans
DNA Copy Number Variations
Genetic Predisposition to Disease
Schizophrenia
Autistic Disorder
Genomics

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37515924
DOI: 10.1016/j.conb.2023.102750
PMCID: PMC10529795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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