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Article

Modeling Drug-Induced Neuropathy Using Human iPSCs for Predictive Toxicology.

Clinical pharmacology and therapeutics - 1 Jun 2017

Ohara R, Imamura K, Morii F, Egawa N, Tsukita K, Enami T, Shibukawa R, Mizuno T, Nakagawa M, Inoue H

Abstract excerpt

Drugs under development can cause unpredicted toxicity in humans due to differential drug responsiveness between humans and other disease models, resulting in clinical trial failures. Human induced pluripotent stem cells (iPSCs) are expected to represent a useful tool for toxicity testing. However, among many assays, appropriate cellular assays for predicting neurotoxicity in an iPSC-based model are still...

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Identifiers

PMID: 27859025
DOI: 10.1002/cpt.562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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