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Functional Neurons Generated from T Cell-Derived Induced Pluripotent Stem Cells for Neurological Disease Modeling

20 Feb 2016

Abstract excerpt

Modeling of neurological diseases using induced pluripotent stem cells (iPSCs) derived from the somatic cells of patients has provided a means of elucidating pathogenic mechanisms and performing drug screening. T cells are an ideal source of patient-specific iPSCs because they can be easily obtained from samples. Recent studies indicated that iPSCs retain an epigenetic memory relating to their cell of origin that...

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Biomedical Ethics and Regulation
CRISPR and Genetic Engineering
Pluripotent Stem Cells Research

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PMID: 26905201
DOI: 10.1016/j.stemcr.2016.01.010

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