Article
A deep phenotyping study in mouse and iPSC models to understand the role of oligodendroglia in optic neuropathy in Wolfram syndrome.
Acta neuropathologica communications - 28 Aug 2024
Ahuja K, Vandenabeele M, Nami F, Lefevere E, Van Hoecke J, Bergmans S, Claes M, Vervliet T, Neyrinck K, Burg T, De Herdt D, Bhaskar P, Zhu Y, Looser Z J, Loncke J, Gsell W, Plaas M, Agostinis P, Swinnen J V, Van Den Bosch L, Bultynck G, Saab A S, Wolfs E, Chai Y C, Himmelreich U, Verfaillie C, Moons L, De Groef L
Abstract excerpt
Wolfram syndrome (WS) is a rare childhood disease characterized by diabetes mellitus, diabetes insipidus, blindness, deafness, neurodegeneration and eventually early death, due to autosomal recessive mutations in the WFS1 (and WFS2) gene. While it is categorized as a neurodegenerative disease, it is increasingly becoming clear that other cell types besides neurons may be affected and contribute to the...
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