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Article

Whole-Exome Sequencing Study of Thyrotropin-Secreting Pituitary Adenomas.

The Journal of clinical endocrinology and metabolism - 1 Feb 2017

Sapkota Santosh, Horiguchi Kazuhiko, Tosaka Masahiko, Yamada Syozo, Yamada Masanobu

Abstract excerpt

Context: Thyrotropin (TSH)-secreting pituitary adenomas (TSHomas) are a rare cause of hyperthyroidism, and the genetic aberrations responsible remain unknown. Objective: To identify somatic genetic abnormalities in TSHomas. Design and Setting: A single-nucleotide polymorphism (SNP) array analysis was performed on 8 TSHomas. Four tumors with no allelic losses or limited loss of heterozygosity were selected, and...

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Topics

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Share to DNA Copy Number Variations
Share to Adenoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Sequence Analysis, DNA

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Source

Identifiers

PMID: 27854551
DOI: 10.1210/jc.2016-2261

Genes

ASTN2
CWH43
SMOX
SYTL3
ZSCAN23

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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