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Article

Somatic RET Indels in Sporadic Medullary Thyroid Cancer: Prevalence and Response to Selpercatinib.

The Journal of clinical endocrinology and metabolism - 14 Jul 2022

Elisei Rossella, Ciampi Raffaele, Matrone Antonio, Prete Alessandro, Gambale Carla, Ramone Teresa, Simeakis George, Materazzi Gabriele, Torregrossa Liborio, Ugolini Clara, Romei Cristina

Abstract excerpt

CONTEXT: Although the majority of RET alterations are single nucleotide variants (SNV), small deletions and/or insertions have been reported at variable prevalence. No information about the efficacy of RET-specific inhibitors in patients harboring RET indels has been provided. OBJECTIVE: We present an update on the prevalence of RET indels in medullary thyroid cancer (MTC) and describe the efficacy of...

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Identifiers

PMID: 35616103
DOI: 10.1210/clinem/dgac325

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