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Article

Whole-exome sequencing studies of nonhereditary (sporadic) parathyroid adenomas.

The Journal of clinical endocrinology and metabolism - 1 Oct 2012

Newey Paul J, Nesbit M Andrew, Rimmer Andrew J, Attar Moustafa, Head Rosie T, Christie Paul T, Gorvin Caroline M, Stechman Michael, Gregory Lorna, Mihai Radu, Sadler Greg, McVean Gil, Buck David, Thakker Rajesh V

Abstract excerpt

CONTEXT: Genetic abnormalities, such as those of multiple endocrine neoplasia type 1 (MEN1) and Cyclin D1 (CCND1) genes, occur in <50% of nonhereditary (sporadic) parathyroid adenomas. OBJECTIVE: To identify genetic abnormalities in nonhereditary parathyroid adenomas by whole-exome sequence analysis. DESIGN: Whole-exome sequence analysis was performed on parathyroid adenomas and leukocyte DNA samples from 16...

Topics

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Adenoma
Cyclin D1
Exome
Hyperparathyroidism, Primary
Multiple Endocrine Neoplasia Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Parathyroid Neoplasms

Shelterin Complex

Telomere-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22855342
DOI: 10.1210/jc.2012-2303
PMCID: PMC4446457

Genes

MEN1
CCND1
POT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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