Article
HSPB3 protein is expressed in motoneurons and induces their survival after lesion-induced degeneration.
Experimental neurology - 1 Dec 2016
La Padula Veronica, Staszewski Ori, Nestel Sigrun, Busch Hauke, Boerries Melanie, Roussa Eleni, Prinz Marco, Krieglstein Kerstin
Abstract excerpt
The human small heat shock proteins (HSPBs) form a family of molecular chaperones comprising ten members (HSPB1-HSPB10), whose functions span from protein quality control to cytoskeletal dynamics and cell death control. Mutations in HSPBs can lead to human disease and particularly point mutations in HSPB1 and HSPB8 are known to lead to peripheral neuropathies. Recently, a missense mutation (R7S) in yet another...
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