Article
ADA3 regulates normal and tumor mammary epithelial cell proliferation through c-MYC.
Breast cancer research : BCR - 16 Nov 2016
Griffin Nicolas I, Sharma Gayatri, Zhao Xiangshan, Mirza Sameer, Srivastava Shashank, Dave Bhavana J, Aleskandarany Mohammed, Rakha Emad, Mohibi Shakur, Band Hamid, Band Vimla
Abstract excerpt
BACKGROUND: We have established the critical role of ADA3 as a coactivator of estrogen receptor (ER), as well as its role in cell cycle progression. Furthermore, we showed that ADA3 is predominantly nuclear in mammary epithelium, and in ER+, but is cytoplasmic in ER- breast cancers, the latter correlating with poor survival. However, the role of nuclear ADA3 in human mammary epithelial cells (hMECs), and in ER+...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.