Article
Genomewide association study of movement-related adverse antipsychotic effects.
Biological psychiatry - 1 Feb 2010
Aberg Karolina, Adkins Daniel E, Bukszár József, Webb Bradley T, Caroff Stanley N, Miller Del D, Sebat Jonathan, Stroup Scott, Fanous Ayman H, Vladimirov Vladimir I, McClay Joseph L, Lieberman Jeffrey A, Sullivan Patrick F, van den Oord Edwin J C G
Abstract excerpt
BACKGROUND: Understanding individual differences in the development of extrapyramidal side effects (EPS) as a response to antipsychotic therapy is essential to individualize treatment. METHODS: We performed genomewide association studies to search for genetic susceptibility to EPS. Our sample consisted of 738 schizophrenia patients, genotyped for 492K single nucleotide polymorphisms (SNPs). We studied three...
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