Article
Microgravity Modifies the Phenotype of Fibroblast and Promotes Remodeling of the Fibroblast-Keratinocyte Interaction in a 3D Co-Culture Model.
International journal of molecular sciences - 16 Feb 2022
Fedeli Valeria, Cucina Alessandra, Dinicola Simona, Fabrizi Gianmarco, Catizone Angela, Gesualdi Luisa, Ceccarelli Simona, Harrath Abdel Halim, Alwasel Saleh H, Ricci Giulia, Pedata Paola, Bizzarri Mariano, Monti Noemi
Abstract excerpt
Microgravity impairs tissue organization and critical pathways involved in the cell-microenvironment interplay, where fibroblasts have a critical role. We exposed dermal fibroblasts to simulated microgravity by means of a Random Positioning Machine (RPM), a device that reproduces conditions of weightlessness. Molecular and structural changes were analyzed and compared to control samples growing in a normal...
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