Article
Identifications of novel mechanisms in breast cancer cells involving duct-like multicellular spheroid formation after exposure to the Random Positioning Machine.
Scientific reports - 27 May 2016
Kopp Sascha, Slumstrup Lasse, Corydon Thomas J, Sahana Jayashree, Aleshcheva Ganna, Islam Tawhidul, Magnusson Nils E, Wehland Markus, Bauer Johann, Infanger Manfred, Grimm Daniela
Abstract excerpt
Many cell types form three-dimensional aggregates (MCS; multicellular spheroids), when they are cultured under microgravity. MCS often resemble the organ, from which the cells have been derived. In this study we investigated human MCF-7 breast cancer cells after a 2 h-, 4 h-, 16 h-, 24 h- and 5d-exposure to a Random Positioning Machine (RPM) simulating microgravity. At 24 h few small compact MCS were detectable,...
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