Article
High-Affinity α-Conotoxin PnIA Analogs Designed on the Basis of the Protein Surface Topography Method.
Scientific reports - 14 Nov 2016
Kasheverov Igor E, Chugunov Anton O, Kudryavtsev Denis S, Ivanov Igor A, Zhmak Maxim N, Shelukhina Irina V, Spirova Ekaterina N, Tabakmakher Valentin M, Zelepuga Elena A, Efremov Roman G, Tsetlin Victor I
Abstract excerpt
Despite some success for small molecules, elucidating structure-function relationships for biologically active peptides - the ligands for various targets in the organism - remains a great challenge and calls for the development of novel approaches. Some of us recently proposed the Protein Surface Topography (PST) approach, which benefits from a simplified representation of biomolecules' surface as projection...
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