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Inhibition of JCPyV infection mediated by targeted viral genome editing using CRISPR/Cas9

14 Nov 2016

Abstract excerpt

Progressive multifocal leukoencephalopathy (PML) is a debilitating disease resulting from infection of oligodendrocytes by the JC polyomavirus (JCPyV). Currently, there is no anti-viral therapeutic available against JCPyV infection. The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9) system (CRISPR/Cas9) is a genome editing tool capable of introducing sequence...

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PMID: 27841295
DOI: 10.1038/srep36921

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