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Article

CRISPR/Cas9 System as an Agent for Eliminating Polyomavirus JC Infection.

PloS one - 1 Jan 2015

Wollebo Hassen S, Bellizzi Anna, Kaminski Rafal, Hu Wenhui, White Martyn K, Khalili Kamel

Abstract excerpt

Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating disease of the central nervous system (CNS) caused by reactivation of the human polyomavirus JCV gene expression and its replication in oligodendrocytes, the myelin producing cells in the brain. Once a rare disease seen in patients with lymphotproliferative and myeloproliferative disorders, PML has been seen more frequently in HIV-1...

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Share to Antigens, Viral, Tumor
Share to CRISPR-Cas Systems
Share to Gene Knockdown Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukoencephalopathy, Progressive Multifocal

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Share to RNA, Guide, CRISPR-Cas Systems

Source

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Identifiers

PMID: 26360417
DOI: 10.1371/journal.pone.0136046
PMCID: PMC4567079

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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