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Article

Exploring the role of NCCR variation on JC polyomavirus expression from dual reporter minicircles.

PloS one - 1 Jan 2018

L'Honneur Anne-Sophie, Leh Hervé, Laurent-Tchenio Fanny, Hazan Uriel, Rozenberg Flore, Bury-Moné Stéphanie

Abstract excerpt

JC virus (JCV), a ubiquitous human polyomavirus, can cause fatal progressive multifocal leukoencephalopathy (PML) in immune compromised patients. The viral genome is composed of two conserved coding regions separated by a highly variable non-coding control region (NCCR). We analyzed the NCCR sequence from 10 PML JCV strains and found new mutations. Remarkably, the NCCR f section was mutated in most cases. We...

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Source

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Identifiers

PMID: 29944671
DOI: 10.1371/journal.pone.0199171
PMCID: PMC6019678

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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