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Article

Prothymosin-α interacts with mutant huntingtin and suppresses its cytotoxicity in cell culture.

The Journal of biological chemistry - 6 Jan 2012

Dong Gaofeng, Callegari Eduardo A, Gloeckner Christian J, Ueffing Marius, Wang Hongmin

Abstract excerpt

Huntington disease (HD), a fatal neurodegenerative disorder, is caused by a lengthening of the polyglutamine tract in the huntingtin (Htt) protein. Despite considerable effort, thus far there is no cure or treatment available for the disorder. Using the approach of tandem affinity purification we recently discovered that prothymosin-α (ProTα), a small highly acidic protein, interacts with mutant Htt (mHtt). This...

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Identifiers

PMID: 22110140
DOI: 10.1074/jbc.M111.294280
PMCID: PMC3256907

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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