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Article

Intrinsic disorder in proteins involved in amyotrophic lateral sclerosis.

Cellular and molecular life sciences : CMLS - 1 Apr 2017

Santamaria Nikolas, Alhothali Marwa, Alfonso Maria Harreguy, Breydo Leonid, Uversky Vladimir N

Abstract excerpt

Five structurally and functionally different proteins, an enzyme superoxide dismutase 1 (SOD1), a TAR-DNA binding protein-43 (TDP-43), an RNA-binding protein FUS, a cofilin-binding protein C9orf72, and polypeptides generated as a result of its intronic hexanucleotide expansions, and to lesser degree actin-binding profilin-1 (PFN1), are considered to be the major drivers of amyotrophic lateral sclerosis. One of...

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Source

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Identifiers

PMID: 27838743
DOI: 10.1007/s00018-016-2416-6
PMCID: PMC11107678

Genes

FUS
PFN1
SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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