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Article

Z16b, a natural compound from Ganoderma cochlear is a novel RyR2 stabilizer preventing catecholaminergic polymorphic ventricular tachycardia.

Acta pharmacologica Sinica - 1 Sept 2022

Wan Jiang-Fan, Wang Gang, Qin Fu-Ying, Huang Dan-Ling, Wang Yan, Su Ai-Ling, Zhang Hai-Ping, Liu Yang, Zeng Shao-Yin, Wei Chao-Liang, Cheng Yong-Xian, Liu Jie

Abstract excerpt

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited, lethal ventricular arrhythmia triggered by catecholamines. Mutations in genes that encode cardiac ryanodine receptor (RyR2) and proteins that regulate RyR2 activity cause enhanced diastolic Ca2+ release (leak) through the RyR2 channels, resulting in CPVT. Current therapies for CPVT are limited. We found that Z16b, a meroterpenoid...

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Identifiers

PMID: 35190699
DOI: 10.1038/s41401-022-00870-1
PMCID: PMC9433431

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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