Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cerebellar volume mediates the relationship between FMR1 mRNA levels and voluntary step initiation in males with the premutation.

Neurobiology of aging - 1 Feb 2017

Hocking Darren R, Birch Rachael C, Bui Quang M, Menant Jasmine C, Lord Stephen R, Georgiou-Karistianis Nellie, Godler David E, Wen Wei, Hackett Anna, Rogers Carolyn, Trollor Julian N

Abstract excerpt

Recent evidence indicates that adults with a premutation (PM: 55-199 CGG repeats) expansion in the fragile X mental retardation 1 (FMR1) gene show postural control deficits that may reflect disruption to cerebellar motor regions. Less is known about the influence of reduced cerebellar volume and structural changes, and increase in CGG repeat and FMR1 mRNA levels on the attentional demands of step initiation in PM...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cerebellum
Share to Cognition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fragile X Mental Retardation Protein

Share to Magnetic Resonance Imaging

Share to Neuroimaging

Share to Postural Balance

Share to Reaction Time

Share to Trinucleotide Repeats

Source

Identifiers

PMID: 27837676
DOI: 10.1016/j.neurobiolaging.2016.10.017

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cerebellar volume mediates the relationship between FMR1 mRNA levels and voluntary step initiation in males with the premutation.PMID 27837676Read ↗

Evidence linking FMR1 mRNA and attentional demands of stepping and postural control in women with the premutation.Semantic proximity Read ↗

Cognitive-motor interference during postural control indicates at-risk cerebellar profiles in females with the FMR1 premutation.Semantic proximity Read ↗

Age and CGG-repeat length are associated with neuromotor impairments in at-risk females with the FMR1 premutation.Semantic proximity Read ↗

Relationships between motor scores and cognitive functioning in FMR1 female premutation X carriers indicate early involvement of cerebello-cerebral pathways.Semantic proximity Read ↗

Relationships between motor scores and cognitive functioning in FMR1 female premutation X carriers indicate early involvement of cerebello-cerebral pathwaysSemantic proximity Read ↗

Clinical Heterogeneity in a Scandinavian FMR1 Premutation Carrier Cohort and Basal Ganglia Atrophy in FXTAS.Semantic proximity Read ↗

Young adult male carriers of the fragile X premutation exhibit genetically modulated impairments in visuospatial tasks controlled for psychomotor speedSemantic proximity Read ↗

Diffusion tensor imaging in male premutation carriers of the fragile X mental retardation geneSemantic proximity Read ↗

Mapping self-reports of working memory deficits to executive dysfunction in Fragile X Mental Retardation 1 (FMR1) gene premutation carriers asymptomatic for FXTAS.Semantic proximity Read ↗

Fragile X-associated tremor/ataxia syndrome: influence of the FMR1 gene on motor fiber tracts in males with normal and premutation alleles.Semantic proximity Read ↗

Abnormal trajectories in cerebellum and brainstem volumes in carriers of the fragile X premutation.Semantic proximity Read ↗

FMR1 CGG repeat length predicts motor dysfunction in premutation carriers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.