Article
Fragile X-associated tremor/ataxia syndrome: influence of the FMR1 gene on motor fiber tracts in males with normal and premutation alleles.
JAMA neurology - 1 Aug 2013
Wang Jun Yi, Hessl David, Schneider Andrea, Tassone Flora, Hagerman Randi J, Rivera Susan M
Abstract excerpt
IMPORTANCE: Individuals with the fragile X premutation express expanded CGG repeats (repeats 55-200) in the FMR1 gene and elevated FMR1 messenger RNA (mRNA) levels, both of which may underlie the occurrence of the late-onset neurodegenerative disorder fragile X-associated tremor/ataxia syndrome (FXTAS). Because the core feature of FXTAS is motor impairment, determining the influence of FMR1 mRNA levels on...
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