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Article

Abnormal trajectories in cerebellum and brainstem volumes in carriers of the fragile X premutation.

Neurobiology of aging - 1 Jul 2017

Wang Jun Yi, Hessl David, Hagerman Randi J, Simon Tony J, Tassone Flora, Ferrer Emilio, Rivera Susan M

Abstract excerpt

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder typically affecting male premutation carriers with 55-200 CGG trinucleotide repeat expansions in the FMR1 gene after age 50. The aim of this study was to examine whether cerebellar and brainstem changes emerge during development or aging in late life. We retrospectively analyzed magnetic resonance imaging scans from 322...

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Identifiers

PMID: 28391068
DOI: 10.1016/j.neurobiolaging.2017.03.018
PMCID: PMC5498112

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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