Article

An expression-directed linear mixed model (edLMM) discovering low-effect genetic variants

2023-07-15

Abstract excerpt

Detecting genetic variants with low effect sizes using a moderate sample size is difficult, hindering downstream efforts to learn pathology and estimating heritability. In this work, by utilizing informative weights learned from training genetically predicted gene expression models, we formed an alternative approach to estimate the polygenic term in a linear mixed model (LMM). Our LMM estimates the genetic backgro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 86cd3042-74c3-5252-be26-a6448be39f49
DOI: 10.1101/2023.07.13.548939

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An expression-directed linear mixed model (edLMM) discovering low-effect genetic variantsDOI 10.1101/2023.07.13.548939Read

An expression-directed linear mixed model discovering low-effect genetic variants.Semantic proximity Read

Survey of the Heritability and Sparse Architecture of Gene Expression Traits across Human Tissues.Semantic proximity Read

A generalized linear mixed model association tool for biobank-scale data.Semantic proximity Read

Survey of the Heritability and Sparse Architecture of Gene Expression Traits Across Human TissuesSemantic proximity Read

Differential gene expression analysis based on linear mixed model corrects false positive inflation for studying quantitative traits.Semantic proximity Read

gRely: Relyability for genome trained sequence-to-expression modelsSemantic proximity Read

A Robust Method Uncovers Significant Context-Specific Heritability in Diverse Complex Traits.Semantic proximity Read

Multikernel linear mixed models for complex phenotype prediction.Semantic proximity Read

Accurate and Scalable Construction of Polygenic Scores in Large Biobank Data Sets.Semantic proximity Read

Deep learning approaches for non-coding genetic variant effect prediction: current progress and future prospects.Semantic proximity Read

Evaluating the informativeness of deep learning annotations for human complex diseasesSemantic proximity Read

Multikernel linear mixed model with adaptive lasso for complex phenotype prediction.Semantic proximity Read