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Article

Local and transient gene expression primes the liver to resist cancer metastasis

9 Nov 2016

Abstract excerpt

cancer cells and for recruiting immunosuppressive cells to areas of inflammation. Therefore, reducing CXCL12 concentrations within the liver has the potential to decrease tumor and immunosuppressive cell activation/migration within the liver. However, because of off-target toxicities associated with systemic administration of anti-CXCL12 therapies, transient and liver-specific expression of a CXCL12 trap is...

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PMID: 27831902
DOI: 10.1126/scitranslmed.aag2306

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