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Article

A structural model for the ternary cleavable complex formed between human topoisomerase I, DNA, and camptothecin.

Biochemistry - 21 Aug 2001

Kerrigan J E, Pilch D S

Abstract excerpt

Using the X-ray crystal structure of the human topoisomerase I (TOP1)-DNA cleavable complex, we have developed a general model for the ternary drug-DNA-TOP1 cleavable complex formed with camptothecin (CPT) and its analogues. This model has the drug intercalated between the -1 and +1 base pairs, with the E-ring pointing into the minor groove and the A-ring directed toward the major groove. The ternary complex is...

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Identifiers

PMID: 11502172
DOI: 10.1021/bi010913l

Genes

TOP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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