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Article

Inhibition of Human Immunodeficiency Virus (HTV-1) Replication In Vitro by Noncytotoxic Doses of Camptothecin, a Topoisomerase I Inhibitor

1 Jan 1991

Abstract excerpt

We examined the effects of topoisomerase inhibitors on human immunodeficiency virus type 1 (HIV-1) infection of H9 cells in cell culture. Infection is blocked or substantially reduced by the topoisomerase I inhibitor camptothecin (CPT), but not by two topoisomerase II inhibitors. Significant reduction (greater than or equal to 90%) in the amount of virus released, as measured by reverse transcriptase, is obtained...

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Identifiers

PMID: 1707642
DOI: 10.1089/aid.1991.7.65

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Related research

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Inhibition of Human Immunodeficiency Virus (HTV-1) Replication In Vitro by Noncytotoxic Doses of Camptothecin, a Topoisomerase I InhibitorPMID 1707642Read ↗

Camptothecin inhibits Tat-mediated transactivation of type 1 human immunodeficiency virus.Semantic proximity Read ↗

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Camptothecin-stabilized topoisomerase I-DNA adducts cause premature termination of transcriptionSemantic proximity Read ↗

Inhibition of type 1 human immunodeficiency virus replication by a tat antagonist to which the virus remains sensitive after prolonged exposure in vitro.Semantic proximity Read ↗

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