Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations.

doi:10.18632/oncotarget.13106

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Article

Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations.

Oncotarget - 6 Dec 2016

Blanco Gonzalo, Puiggros Anna, Baliakas Panagiotis, Athanasiadou Anastasia, García-Malo MªDolores, Collado Rosa, Xochelli Aliki, Rodríguez-Rivera María, Ortega Margarita, Calasanz Mª José, Luño Elisa, Vargas MªTeresa, Grau Javier, Martínez-Laperche Carolina, Valiente Alberto, Cervera José, Anagnostopoulos Achilles, Gimeno Eva, Abella Eugènia, Stalika Evangelia, Hernández-Rivas Jesús Mª, Ortuño Francisco José, Robles Diego, Ferrer Ana, Ivars David, González Marcos, Bosch Francesc, Abrisqueta Pau, Stamatopoulos Kostas, Espinet Blanca

Abstract excerpt

Patients with chronic lymphocytic leukemia (CLL) harboring TP53 aberrations (TP53abs; chromosome 17p deletion and/or TP53 mutation) exhibit an unfavorable clinical outcome. Chromosome 8 abnormalities, namely losses of 8p (8p-) and gains of 8q (8q+) have been suggested to aggravate the outcome of patients with TP53abs. However, the reported series were small, thus hindering definitive conclusions. To gain insight...

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PMID: 27821812
DOI: 10.18632/oncotarget.13106
PMCID: PMC5348364

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