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Article

Increased Notch3 Activity Mediates Pathological Changes in Structure of Cerebral Arteries.

Hypertension (Dallas, Tex. : 1979) - 1 Jan 2017

Baron-Menguy Celine, Domenga-Denier Valérie, Ghezali Lamia, Faraci Frank M, Joutel Anne

Abstract excerpt

CADASIL (Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy), the most frequent genetic cause of stroke and vascular dementia, is caused by highly stereotyped mutations in the NOTCH3 receptor, which is predominantly expressed in vascular smooth muscle. The well-established TgNotch3R169C mouse model develops characteristic features of the human disease, with deposition of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscle, Smooth, Vascular

Share to Receptor, Notch3

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Source

Open in PubMed Open full text

Identifiers

PMID: 27821617
DOI: 10.1161/HYPERTENSIONAHA.116.08015
PMCID: PMC5145742

Genes

TIMP3
NOTCH3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Increased Notch3 Activity Mediates Pathological Changes in Structure of Cerebral Arteries.PMID 27821617Read ↗

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