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Article

Reducing T imp3 or vitronectin ameliorates disease manifestations in CADASIL mice

9 Dec 2015

Abstract excerpt

OBJECTIVE: CADASIL is a genetic paradigm of cerebral small vessel disease caused by NOTCH3 mutations that stereotypically lead to the extracellular deposition of NOTCH3 ectodomain (Notch3(ECD) ) on the vessels. TIMP3 and vitronectin are 2 extracellular matrix proteins that abnormally accumulate in Notch3(ECD) -containing deposits on brain vessels of mice and patients with CADASIL. Herein, we investigated whether...

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PMID: 26648042
DOI: 10.1002/ana.24573

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