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Differential Penicillin-Binding Protein 5 (PBP5) Levels in the Enterococcus faecium Clades with Different Levels of Ampicillin Resistance.

Antimicrobial agents and chemotherapy - 1 Jan 2017

Montealegre Maria Camila, Roh Jung Hyeob, Rae Meredith, Davlieva Milya G, Singh Kavindra V, Shamoo Yousif, Murray Barbara E

Abstract excerpt

Ampicillin resistance in Enterococcus faecium is a serious concern worldwide, complicating the treatment of E. faecium infections. Penicillin-binding protein 5 (PBP5) is considered the main ampicillin resistance determinant in E. faecium The three known E. faecium clades showed sequence variations in the pbp5 gene that are associated with their ampicillin resistance phenotype; however, these changes alone do not...

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Identifiers

PMID: 27821450
DOI: 10.1128/AAC.02034-16
PMCID: PMC5192164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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