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Enterococcus faecium PBP5-S/R, the missing link between PBP5-S and PBP5-R.

Antimicrobial agents and chemotherapy - 1 Nov 2014

Pietta Ester, Montealegre Maria Camila, Roh Jung Hyeob, Cocconcelli Pier Sandro, Murray Barbara E

Abstract excerpt

During a study to investigate the evolution of ampicillin resistance in Enterococcus faecium, we observed that a number of E. faecium strains, mainly from the recently described subclade A2, showed PBP5 sequences in between PBP5-S and PBP5-R. These hybrid PBP5-S/R patterns reveal a progression of amino acid changes from the S form to the R form of this protein; however, these changes do not strictly correlate...

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Identifiers

PMID: 25182648
DOI: 10.1128/AAC.03648-14
PMCID: PMC4249377

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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