Article
Penicillin-binding protein 5 sequence alterations in clinical isolates of Enterococcus faecium with different levels of beta-lactam resistance.
The Journal of infectious diseases - 1 Jul 1998
Rybkine T, Mainardi J L, Sougakoff W, Collatz E, Gutmann L
Abstract excerpt
The low-affinity penicillin-binding protein (PBP) 5 is the main beta-lactam target and is responsible for resistance to this class of antibiotics in Enterococcus faecium. The PBP 5 variants of 15 clinical isolates (including 8 resistant to vancomycin) with different levels of beta-lactam resistan...
Topics
- Amino Acid Sequence
- Amino Acid Substitution
- Ampicillin
- Bacterial Proteins
- Carrier Proteins
- Drug Resistance, Microbial
- Enterococcus faecium
- Genetic Variation
- Gram-Positive Bacterial Infections
- Hexosyltransferases
- Humans
- Imipenem
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Muramoylpentapeptide Carboxypeptidase
- Penicillin G
- Penicillin Resistance
- Penicillin-Binding Proteins