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Article

Altered Plasmodium falciparum Sensitivity to the Antiretroviral Protease Inhibitor Lopinavir Associated with Polymorphisms in pfmdr1.

Antimicrobial agents and chemotherapy - 1 Jan 2017

Sonoiki Ebere, Nsanzabana Christian, Legac Jennifer, Sindhe Kirthana M V, DeRisi Joseph, Rosenthal Philip J

Abstract excerpt

The HIV protease inhibitor lopinavir inhibits Plasmodium falciparum aspartic proteases (plasmepsins) and parasite development, and children receiving lopinavir-ritonavir experienced fewer episodes of malaria than those receiving other antiretroviral regimens. Resistance to lopinavir was selected in vitro over ∼9 months, with ∼4-fold decreased sensitivity. Whole-genome sequencing of resistant parasites showed a...

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Source

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Identifiers

PMID: 27821443
DOI: 10.1128/AAC.01949-16
PMCID: PMC5192118

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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