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Article

Structural analysis of an HIV-1 protease I47A mutant resistant to the protease inhibitor lopinavir.

Protein science : a publication of the Protein Society - 1 Jul 2005

Kagan Ron M, Shenderovich Mark D, Heseltine Peter N R, Ramnarayan Kal

Abstract excerpt

We have identified a rare HIV-1 protease (PR) mutation, I47A, associated with a high level of resistance to the protease inhibitor lopinavir (LPV) and with hypersusceptibility to the protease inhibitor saquinavir (SQV). The I47A mutation was found in 99 of 112,198 clinical specimens genotyped after LPV became available in late 2000, but in none of 24,426 clinical samples genotyped from 1998 to October 2000....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15937277
DOI: 10.1110/ps.051347405
PMCID: PMC2253353

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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