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Article

Prevalence of the HIV-1 protease mutation I47A in clinical practice and association with lopinavir resistance.

AIDS (London, England) - 24 Apr 2006

de Mendoza Carmen, Valer Luisa, Bacheler Lee, Pattery Theresa, Corral Angélica, Soriano Vincent

Abstract excerpt

Mutation proI47A has recently been associated with lopinavir/ritonavir (LPV/r) resistance. Only four out of 1859 specimens (0.2%) sent for drug resistance testing (219 drug-naive and 1650 antiretroviral-experienced) showed I47A. All belonged to patients failing LPV/r. The prevalence among protease inhibitor-experienced patients was 0.6%. Phenotypic testing showed that proI47A caused high-level lopinavir...

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PMID: 16603864
DOI: 10.1097/01.aids.0000222084.44411.cc

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