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Comparative pangenomics of Streptococcus pneumoniae from Malawi: uncovering genetic variability and pathogenicity.

Microbial genomics - 1 Apr 2025

Iranzadeh Arash, Alisoltani Arghavan, Kiran Anmol M, Breiman Robert F, Chaguza Chrispin, Peno Chikondi, Cornick Jennifer E, Everett Dean B, Mulder Nicola

Abstract excerpt

Streptococcus pneumoniae is a significant cause of bacterial infections, including pneumonia, meningitis and septicemia, primarily affecting children, the elderly and immunocompromised individuals. This study aimed to elucidate the serotype and lineage distribution and molecular mechanisms underlying pneumococcal invasiveness through a comprehensive pangenomic analysis of 1416 isolates from Malawi. Our analysis...

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Identifiers

PMID: 40232949
DOI: 10.1099/mgen.0.001370
PMCID: PMC12282314

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