Article
Association of IFIH1 and pro-inflammatory mediators: Potential new clues in SLE-associated pathogenesis.
PloS one - 1 Jan 2017
Munroe Melissa E, Pezant Nathan, Brown Michael A, Fife Dustin A, Guthridge Joel M, Kelly Jennifer A, Wiley Graham, Gaffney Patrick M, James Judith A, Montgomery Courtney G
Abstract excerpt
Antiviral defenses are inappropriately activated in systemic lupus erythematosus (SLE) and association between SLE and the antiviral helicase gene, IFIH1, is well established. We sought to extend the previously reported association of pathogenic soluble mediators and autoantibodies with mouse Mda5 to its human ortholog, IFIH1. To better understand the role this gene plays in human lupus, we assessed association...
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