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The natural history study of preclinical genetic Creutzfeldt-Jakob Disease (CJD): A prospective longitudinal study protocol

2022-12-08

Abstract excerpt

<h4>Background: </h4> Creutzfeldt-Jakob Disease (CJD) is the most common prion disease in humans causing a rapidly progressive neurological decline and dementia and is invariably fatal. The familial forms (genetic CJD, gCJD) are caused by mutations in the PRNP gene encoding for the prion protein (PrP). In Israel, there is a large cluster of gCJD cases, carriers of an E200K mutation in the PRNP gene, and therefore...

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Literature Corpus work: 1b1d42b3-3536-5edf-b8d2-34dff9b1e021
DOI: 10.21203/rs.3.rs-2326711/v1

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