Article
Integrative analysis of DNA copy number, DNA methylation and gene expression in multiple myeloma reveals alterations related to relapse.
Oncotarget - 6 Dec 2016
Krzeminski Patryk, Corchete Luis A, García Juan L, López-Corral Lucía, Fermiñán Encarna, García Eva M, Martín Ana A, Hernández-Rivas Jesús M, García-Sanz Ramón, San Miguel Jesús F, Gutiérrez Norma C
Abstract excerpt
Multiple myeloma (MM) remains incurable despite the introduction of novel agents, and a relapsing course is observed in most patients. Although the development of genomic technologies has greatly improved our understanding of MM pathogenesis, the mechanisms underlying relapse have been less thoroughly investigated. In this study, an integrative analysis of DNA copy number, DNA methylation and gene expression was...
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