Comprehensive genomic analysis of refractory multiple myeloma reveals a complex mutational landscape associated with drug resistance and novel therapeutic vulnerabilities.

doi:10.3324/haematol.2021.279360

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Article

Comprehensive genomic analysis of refractory multiple myeloma reveals a complex mutational landscape associated with drug resistance and novel therapeutic vulnerabilities.

Haematologica - 1 Aug 2022

Giesen Nicola, Paramasivam Nagarajan, Toprak Umut H, Huebschmann Daniel, Xu Jing, Uhrig Sebastian, Samur Mehmet, Bähr Stella, Fröhlich Martina, Mughal Sadaf S, Mai Elias K, Jauch Anna, Müller-Tidow Carsten, Brors Benedikt, Munshi Nikhil, Goldschmidt Hartmut, Weinhold Niels, Schlesner Matthias, Raab Marc S

Abstract excerpt

The outcomes of patients with multiple myeloma (MM) refractory to immunomodulatory agents (IMiDs) and proteasome inhibitors (PIs) remain poor. In this study, we performed whole genome and transcriptome sequencing of 39 heavily pretreated relapsed/refractory MM (RRMM) patients to identify mechanisms of resistance and potential therapeutic targets. We observed a high mutational load and indications of increased...

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Identifiers

PMID: 35045690
DOI: 10.3324/haematol.2021.279360
PMCID: PMC9335090

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