Article
Nuclear Magnetic Resonance Structure and Mutational Analysis of the Lactococcin A Immunity Protein.
Biochemistry - 15 Nov 2016
Kristiansen Per Eugen, Persson Cecilia, Fuochi Virginia, Pedersen Anders, Karlsson Göran B, Nissen-Meyer Jon, Oppegård Camilla
Abstract excerpt
The class IId bacteriocin lactococcin A and the pediocin-like bacteriocins induce membrane leakage and cell death by specifically binding the mannose phophotransferase system (man-PTS) on their target cells. The bacteriocins' cognate immunity proteins that protect the producer cell from its own bacteriocin recognize and bind to the bacteriocin-man-PTS complex and thereby block membrane leakage. In this study, we...
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