Article
Structural analysis and comparison of the C-terminal transport signal domains of hemolysin A and leukotoxin A.
FEBS letters - 5 Jun 1995
Yin Y, Zhang F, Ling V, Arrowsmith C H
Abstract excerpt
NMR spectroscopy was used to study the structure of the C-terminal signal sequences of the bacterial toxins, hemolysin A(HlyA) and leukotoxin A (LktA). The two signals share little sequence homology; however, both can direct toxin transport with equal efficiency. We report here that in a membrane mimetic environment both peptides form two short non-interacting alpha-helices separated by a short loop. This higher...
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