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Article

Role of d -Alanylation ofStreptococcus gordoniiLipoteichoic Acid in Innate and Adaptive Immunity

10 Apr 2007

Abstract excerpt

In recent years, there has been considerable interest in using the oral commensal gram-positive bacterium Streptococcus gordonii as a live vaccine vector. The present study investigated the role of d-alanylation of lipoteichoic acid (LTA) in the interaction of S. gordonii with the host innate and adaptive immune responses. A mutant strain defective in d-alanylation was generated by inactivation of the dltA gene...

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PMID: 17420241
DOI: 10.1128/iai.01549-06

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