Article
High-fat-diet induced development of increased fasting glucose levels and impaired response to intraperitoneal glucose challenge in the collaborative cross mouse genetic reference population.
BMC genetics - 5 Jan 2016
Atamni Hanifa J Abu-Toamih, Mott Richard, Soller Morris, Iraqi Fuad A
Abstract excerpt
BACKGROUND: The prevalence of Type 2 Diabetes (T2D) mellitus in the past decades, has reached epidemic proportions. Several lines of evidence support the role of genetic variation in the pathogenesis of T2D and insulin resistance. Elucidating these factors could contribute to developing new medical treatments and tools to identify those most at risk. The aim of this study was to characterize the phenotypic...
Topics
- Animals
- Blood Glucose
- Crosses, Genetic
- Diabetes Mellitus, Type 2
- Diet, High-Fat
- Disease Susceptibility
- Fasting
- Female
- Glucose
- Injections, Intraperitoneal
- Male
- Mice
- Phenotype
- Sex Factors